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001大大,为什么你们谈来谈起说的都是常染,Y很不重要吗?不值得一提,还是说在人群划分主要看常染,田园洞人的基因组 不包括Y染色体吗?
大凌河 发表于 2017-10-14 21:55
y也很重要,是一个很好的源流标记,不过从DNA的角度,意义相比常染就不大了,可能除了男性不育症,呵呵
物格而后知至,知至而后意诚,意诚而后心正,心正而后身修,身修而后家齐,家齐而后国治,国治而后天下平...
y也很重要,是一个很好的源流标记,不过从DNA的角度,意义相比常染就不大了,可能除了男性不育症,呵呵
imvivi001 发表于 2017-10-14 22:00
1,这次测序包括Y吗?
2,是没测还是没测出来?
3,  还是测出来了暂时不公布
4,常染一篇文章,Y另外一篇文章,以后再发,还是田园洞人的测试就到此为止了。

001大大,我这四个问题,您怎么看。
通过捕获测序的方法,付巧妹和同事对田园洞人进行了全面的遗传学分析,他们报道了田园洞人基因组上的370万个变异位点(variable SNPs),基本涵盖基因组每个染色体上的相关群体遗传信息。--------从字面上分析,Y应该还是测了,也应该是有结果了。
通过捕获测序的方法,付巧妹和同事对田园洞人进行了全面的遗传学分析,他们报道了田园洞人基因组上的370万个变异位点(variable SNPs),基本涵盖基因组每个染色体上的相关群体遗传信息。--------从字面上分析,Y应该 ...
大凌河 发表于 2017-10-14 22:28
我估摸着这个消息他们是打算一点点的透露,不急于告诉你们结果。
我估摸着这个消息他们是打算一点点的透露,不急于告诉你们结果。
wanhuatong 发表于 2017-10-14 22:32
测一回,多发几篇文章,你说的有道理
许多内幕俺也不清楚,呜呜呜~
物格而后知至,知至而后意诚,意诚而后心正,心正而后身修,身修而后家齐,家齐而后国治,国治而后天下平...
423# 大凌河
或许你猜的对,很有可能是C1a*
物格而后知至,知至而后意诚,意诚而后心正,心正而后身修,身修而后家齐,家齐而后国治,国治而后天下平...
SUMMARY
By at least 45,000 years before present, anatomically modern humans had spread across Eurasia [1–3], but it is not well known how diverse these early populations were and whether they contributed substantially to later people or represent early modern human expansions into Eurasia that left no surviving descendants today.
Analyses of genome-wide data from several ancient individuals from Western Eurasia and Siberia have shown that some of these individuals have relationships to present-day Europeans [4, 5] while others did not contribute to present-day Eurasian populations [3, 6]. As contributions from Upper Paleolithic populations in Eastern Eurasia to present-day humans and their relationship to other early Eurasians is not clear, we generated genome-wide data from a 40,000-year-old individual from Tianyuan Cave, China, [1, 7] to study his relationship to ancient and present-day humans.
We find that he is more related to present-day and ancient Asians than he is to Europeans, but he shares more alleles with a 35,000-year-old European individual than he shares with other ancient Europeans, indicating that the separation between early Europeans and early Asians was not a single population split. We also find that the Tianyuan individual shares more alleles with some Native American groups in South America than with Native Americans elsewhere, providing further support for population substructure in Asia [8] and suggesting that this persisted from 40,000 years ago until the colonization of the Americas. Our study of the Tianyuan individual highlights the complex migration and subdivision of early human populations in Eurasia
物格而后知至,知至而后意诚,意诚而后心正,心正而后身修,身修而后家齐,家齐而后国治,国治而后天下平...
Comparisons further exploring the South American connection

As in [8], we used D(Amazonians = Surui/Karitiana, Central Americans; P3, Chimp), with many different human populations as P3,
and listed the highest D-statistics in Table S2E. The Tianyuan individual shares more alleles with Amazonians than with Central
Americans, though we fail to reject D(Karitiana, Mixe; Tianyuan, Mbuti/Chimp) = 0 (Table S2E).

The Papuans consistently share more alleles with Amazonians than with Central Americans, but the Onge do not (Table S2E), which differs from a previous study [8], perhaps because we use a different dataset with fewer Onge individuals. When using only transversions, there is a loss of significance in the D-statistics shown in Table S2E, but the Tianyuan individual and Papuan still rank among the top ten highest D-statistics(非常有意思,呵呵

Amazonians share a similarly strong connection to both the Tianyuan individual and Papuan [8]. We expand on the above results to test D(AMER, AMER; P3, Mbuti/Chimp). For P3, we focus on the Tianyuan individual and the Papuan and Onge, but also consider EAS and the Chokhopani1 individual (Table S2H). Some EAS/Papuan/Onge share more alleles with the Surui and Karitiana than with the Quechua, but the Quechua samples are shown to be potentially admixed [8], though unlike the Mixtec, there is no consistent results in the D-statistic analyses here to indicate it is different relative to other Native Americans.
Relative to the Mixe, the Surui share a connection to the Tianyuan individual and the Papuan, and they do not show a connection to
the EAS (Table S2H)(这个可能与早期EE成分有关,而后来的东亚主成分EAS可能因为与后期ASE混合,开始偏离早期的EE了)
物格而后知至,知至而后意诚,意诚而后心正,心正而后身修,身修而后家齐,家齐而后国治,国治而后天下平...
田园洞的全基因组数据,预计稍候会在文献中给出,通常会更新到NCBI或者别的在线数据,大家一起看一下,出来,可以对Y-dna分一下型。
新技术方案尝试:低覆盖全基因组,最低成本深度解析父系源流,略有成效,大家一起摸索。微博@好奇云怪 QQ群:387100816。
田园洞的全基因组数据,预计稍候会在文献中给出,通常会更新到NCBI或者别的在线数据,大家一起看一下,出来,可以对Y-dna分一下型。
Yungsiyebu 发表于 2017-10-20 13:53
很有可能覆盖率太低而分不出,否则会提到的。
极品猥琐凤凰眼镜生物党棍左棍五毛愤青爱国
eight代 poor农 root正 shoot

很有可能覆盖率太低而分不出,否则会提到的。
一统浆糊 发表于 2017-10-20 22:44
有这个可能性,因为之前媒体采访时说是拼凑式‘全序’,不排除y上读取数据有限~
物格而后知至,知至而后意诚,意诚而后心正,心正而后身修,身修而后家齐,家齐而后国治,国治而后天下平...
这次的原始数据已经公布了,但是其中没有包含Y
https://trace.ncbi.nlm.nih.gov/Traces/sra/?run=ERR1910473
本帖最后由 guwei0001 于 2017-10-21 16:52 编辑
觉得这种绿色的成分不应该被称作印度成分,或者是受印度影响,比较可能是在南亚和南岛人南下之前当地的土著成分,当然这些土著和南印度人群是比较接近的
Lep1dus 发表于 2017-9-19 20:09
http://www.doc88.com/p-4971262519107.html
高棉.png

   付团队这次发布的这张现代智人“源流谱系图(上面的图3D)”来看,有一个现象值得我们高度重视,目前发现的亚欧尼人可以分为五大类(稍微宽泛一点是六类,因为丹人其实也是94%的尼人混了6%的另一种‘海德堡远亲’的成分),其中有一类对我们现在的“非非洲裔(更准确的说是nAA后裔而不是OoA后裔)”影响最大,从图中来看,是咱们‘出非洲祖先’与非洲亲戚以及与彼时非洲亲戚差不多的所谓的‘Basal Eurasian’分离之后,与亚洲尼人有一次较大大规模的混合,极有可能发生在西南亚靠近波斯湾附近。...
imvivi001 发表于 2017-10-13 19:38
今天在外边,目前还没有认真看原始数据。不过感觉这次付团队没有认真研究onge人群的常染成分,这个很有可能是一个不容忽视的疏忽~
物格而后知至,知至而后意诚,意诚而后心正,心正而后身修,身修而后家齐,家齐而后国治,国治而后天下平...
这次的原始数据已经公布了,但是其中没有包含Y
https://trace.ncbi.nlm.nih.gov/Traces/sra/?run=ERR1910473
wmch_928 发表于 2017-10-21 15:26
测序数据应当有,下载看看。
新技术方案尝试:低覆盖全基因组,最低成本深度解析父系源流,略有成效,大家一起摸索。微博@好奇云怪 QQ群:387100816。
http://www.doc88.com/p-4971262519107.html
guwei0001 发表于 2017-10-21 16:49
这个大家应该都知道的,但中南半岛所有绿色成分都是印度来的呢?个人在上面已经表达了反对的理由,南岛人带去澳洲不带蓝色的绿色成分不可能从印度来的,而且你上面所举的印度影响时间上也低于南岛人南下时间。个人觉得你上面所说的具有启发性的观点是东南亚土著常染分析中会被计算成一部分绿色一部分紫色这一点,虽然个人有点怀疑,因为整个东南亚和澳美地区在能航海的南岛人南下之前地理阻隔是明显严重的,但还是承认有很大可能性和合理性,所以还要再想想。很多常染分析算法往往缺少纯粹的澳美成分,所以分析起来有困难
还有一个问题。
为什么古人的特异突变数,或者说是遗传距离(红星)往往比现代人(黄星)要多?
岂不闻时间长而突变多乎?好像这些古人是来自未来。
一统浆糊 发表于 2017-10-14 21:13
古DNA降解或者发生其它变化的多,导致测出不少假突变。
O3a3c* (M134+, M117-)
古DNA降解或者发生其它变化的多,导致测出不少假突变。
hercules 发表于 2017-10-26 21:13
谢谢,这样的话看待古代数据要谨慎。
极品猥琐凤凰眼镜生物党棍左棍五毛愤青爱国
eight代 poor农 root正 shoot
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